Placental DNA methylation as a proxy for fetal neurodevelopment and sex-specific associations with in utero particulate air pollution
نویسندگان
چکیده
Background and aims Exposure to particulate matter (PM) air pollution during pregnancy may affect human fetal development. Epigenetic mechanisms are believed to play an essential role in the developmental changes during early life. Within the ENVIRONAGE birth cohort, we investigated whether in utero exposure to PM is associated with differences in placental DNA methylation of genes involved in early neurodevelopment, i.e., Brain-Derived Neurotrophic Factor (BDNF), Leptin (LEP) and 5Hydroxytryptamine (serotonin) receptor 2A (HTR2A).
منابع مشابه
Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort
BACKGROUND Particulate matter with a diameter ≤ 2.5 μm (PM2.5) affects human fetal development during pregnancy. Oxidative stress is a putative mechanism by which PM2.5 may exert its effects. Leptin (LEP) is an energy-regulating hormone involved in fetal growth and development. OBJECTIVES We investigated in placental tissue whether DNA methylation of the LEP promoter is associated with PM2.5 ...
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عنوان ژورنال:
دوره 73 شماره
صفحات -
تاریخ انتشار 2015